Vesicle-associated membrane protein 7

Vesicle-associated membrane protein 7 (VAMP-7), is a protein that in humans is encoded by the VAMP7 gene also known as the SYBL1 gene.^[4][5][6]

VAMP7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DMW
Identifiers
Aliases	VAMP7, SYBL1, TI-VAMP, TIVAMP, VAMP-7, vesicle associated membrane protein 7
External IDs	OMIM: 300053; MGI: 1096399; HomoloGene: 4121; GeneCards: VAMP7; OMA:VAMP7 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 and Yq12 Start 155,881,345 bp[1] End 155,943,769 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte monocyte endothelial cell visceral pleura parietal pleura glomerulus trabecular bone kidney tubule metanephric glomerulus tibia n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SNARE binding SNAP receptor activity syntaxin binding protein binding Cellular component extracellular exosome transport vesicle pseudopodium cytoplasm transport vesicle membrane synapse integral component of membrane trans-Golgi network azurophil granule membrane Golgi apparatus cell junction platelet alpha granule intracellular membrane-bounded organelle lamellipodium apical part of cell neuron projection membrane cell surface phagocytic vesicle membrane endoplasmic reticulum perinuclear region of cytoplasm endoplasmic reticulum membrane secretory granule secretory granule membrane lysosome cytoplasmic vesicle late endosome membrane endosome phagocytic vesicle plasma membrane lysosomal membrane SNARE complex clathrin-coated vesicle membrane synaptic vesicle integral component of synaptic vesicle membrane hippocampal mossy fiber to CA3 synapse Biological process autophagosome maturation vesicle transport along microtubule vesicle fusion with Golgi apparatus Golgi to plasma membrane protein transport positive regulation of histamine secretion by mast cell SNARE complex assembly calcium-ion regulated exocytosis triglyceride transport endoplasmic reticulum to Golgi vesicle-mediated transport post-Golgi vesicle-mediated transport regulation of protein targeting to vacuolar membrane exocytosis natural killer cell degranulation phagocytosis, engulfment protein transport endosome to lysosome transport positive regulation of dendrite morphogenesis vesicle fusion vesicle-mediated transport neutrophil degranulation eosinophil degranulation endocytosis membrane organization transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6845 20955 Ensembl ENSG00000124333 ENSMUSG00000051412 UniProt P51809 P70280 RefSeq (mRNA) NM_001145149 NM_001185183 NM_005638 NM_001302138 NM_011515 NM_001359151 RefSeq (protein) NP_001138621 NP_001172112 NP_005629 NP_001289067 NP_035645 NP_001346080 Location (UCSC) Chr X: 155.88 – 155.94 Mb n/a PubMed search [2] [3]
Wikidata
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Function

VAMP-7 is a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. VAMP-7 localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes.^[6]

Interactions

VAMP-7 has been shown to interact with SNAP23^[7][8] and AP3D1.^[7]