VAV2

Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.^[5][6]

VAV2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DLZ, 2DM1, 2LNW, 2LNX, 4ROJ
Identifiers
Aliases	VAV2, VAV-2, vav guanine nucleotide exchange factor 2
External IDs	OMIM: 600428; MGI: 102718; HomoloGene: 2530; GeneCards: VAV2; OMA:VAV2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.2 Start 133,761,894 bp[1] End 133,992,604 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 19.36 cM Start 27,152,116 bp[2] End 27,317,045 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland ganglionic eminence ventricular zone body of pancreas right lobe of liver caput epididymis right adrenal cortex corpus epididymis left adrenal cortex jejunal mucosa Top expressed in habenula mesenteric lymph nodes lumbar spinal ganglion medullary collecting duct seminal vesicula cumulus cell seminiferous tubule conjunctival fornix ganglionic eminence molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding metal ion binding protein binding phosphotyrosine residue binding Cellular component cytoplasm cytosol plasma membrane Biological process regulation of cell size intracellular signal transduction Fc-gamma receptor signaling pathway involved in phagocytosis regulation of GTPase activity ephrin receptor signaling pathway positive regulation of phosphatidylinositol 3-kinase activity platelet activation Fc-epsilon receptor signaling pathway vascular endothelial growth factor receptor signaling pathway cell projection assembly angiogenesis positive regulation of apoptotic process regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction cell migration signal transduction lamellipodium assembly small GTPase mediated signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7410 22325 Ensembl ENSG00000160293 ENSMUSG00000009621 UniProt P52735 Q60992 RefSeq (mRNA) NM_001134398 NM_003371 NM_009500 RefSeq (protein) NP_001127870 NP_003362 NP_033526 Location (UCSC) Chr 9: 133.76 – 133.99 Mb Chr 2: 27.15 – 27.32 Mb PubMed search [3] [4]
Wikidata
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VAV2 is the second member of the VAV oncogene family. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues.^[6]

Interactions

VAV2 is a GEF for RAC1, specifically in fibroblasts VAV2 is necessary for integrin, but not growth factor–dependent activation of RAC leading to lamellipodia formation.^[7] Double DH domain mutations, L342R/L343SVav2 function as a dominant negative, blocking VAV2 GEF activity for RAC1^[7] and a PH domain mutant is required for recruitment of VAV2 to the membrane in order to elicit GEF activity.^[7] VAV2 has also been shown to regulate collagen phagocytosis in a RAC1-dependent manner^[8] and interact with CD19^[9] and Grb2.^[10][11]