Vestigial-like family member 3

VGLL3
Identifiers
Aliases	VGLL3, VGL-3, VGL3, Vestigial-like family member 3, vestigial like family member 3
External IDs	OMIM: 609980; MGI: 1920819; HomoloGene: 53442; GeneCards: VGLL3; OMA:VGLL3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	86,991,149 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	65,663,254 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; saphenous vein; ; placenta; ; parietal pleura; ; superficial temporal artery; ; Achilles tendon; ; pericardium; ; germinal epithelium; ; stromal cell of endometrium; ; visceral pleura;
	Top expressed in
	sciatic nerve; ; gastrula; ; calvaria; ; umbilical cord; ; decidua; ; stroma of bone marrow; ; skin of external ear; ; ascending aorta; ; skin of abdomen; ; transitional epithelium of urinary bladder;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	389136
	73569
	ENSG00000206538
	ENSMUSG00000091243
	A8MV65
	P85442
	NM_016206; NM_001320493; NM_001320494
	NM_028572; NM_001368760; NM_001368761
	NP_001307422; NP_001307423; NP_057290
	NP_082848; NP_001355689; NP_001355690
	Wikidata
View/Edit Human	View/Edit Mouse

Vestigial-like family member 3 is a protein that in humans is encoded by the VGLL3 gene.^[5]

Quick Facts VGLL3, Identifiers ...

This protein is one of four mammalian homologs (VGLL1-4) of the vestigial gene found in the fruit fly Drosophila.^[6] VGLL3 functions as a transcription coregulator by binding to TEA domain (TEAD) transcription factors (TEAD1, TEAD2, TEAD3, TEAD4 ) through its TDU motif.^[6]^[7] VGLL3 has been implicated in various biological processes including myogenesis (formation of muscle tissue), cell proliferation, and cancer progression.^[7] VGLL3 can also promote epithelial-to-mesenchymal transition (EMT) and cell motility in certain cancer types, suggesting it may play a role in tumor development and metastasis.^[7]

See also