Visinin-like protein 1

Visinin-like protein 1 is a protein that in humans is encoded by the VSNL1 gene.^[5][6][7]

VSNL1
Identifiers
Aliases	VSNL1, HLP3, HPCAL3, HUVISL1, VILIP, VILIP-1, visinin like 1
External IDs	OMIM: 600817; MGI: 1349453; HomoloGene: 2542; GeneCards: VSNL1; OMA:VSNL1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p24.2 Start 17,539,126 bp[1] End 17,657,018 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.1 Start 11,375,243 bp[2] End 11,486,614 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 orbitofrontal cortex Pons superior frontal gyrus endothelial cell Brodmann area 10 Brodmann area 46 Occipital Lobe primary visual cortex Top expressed in lateral septal nucleus primary motor cortex superior colliculus pontine nuclei ventral tegmental area mammillary body medial dorsal nucleus central gray substance of midbrain lobe of cerebellum lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding metal ion binding Cellular component cytosol membrane Biological process positive regulation of exocytosis positive regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of insulin secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7447 26950 Ensembl ENSG00000163032 ENSMUSG00000054459 UniProt P62760 P62761 RefSeq (mRNA) NM_003385 NM_012038 NM_001378929 RefSeq (protein) NP_003376 NP_001353732 NP_001353733 NP_001353734 NP_001353735 NP_036168 NP_001365858 Location (UCSC) Chr 2: 17.54 – 17.66 Mb Chr 12: 11.38 – 11.49 Mb PubMed search [3] [4]
Wikidata
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This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins.^[8]

The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.^[7]