VIPR1

Vasoactive intestinal polypeptide receptor 1 also known as VPAC₁, is a protein, that in humans is encoded by the VIPR1 gene.^[5] VPAC₁ is expressed in the brain (cerebral cortex, hippocampus, amygdala), lung, prostate, peripheral blood leukocytes, liver, small intestine, heart, spleen, placenta, kidney, thymus and testis.^[6][7][8]

VIPR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OF2, 1OGT, 3B3I, 3B6S, 3DTX, 3HCV, 5DEF, 5DEG
Identifiers
Aliases	VIPR1, HVR1, II, PACAP-R-2, PACAP-R2, RDC1, V1RG, VAPC1, VIP-R-1, VIPR, VIRG, VPAC1, VPAC1R, VPCAP1R, vasoactive intestinal peptide receptor 1
External IDs	OMIM: 192321; MGI: 109272; HomoloGene: 3399; GeneCards: VIPR1; OMA:VIPR1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.1 Start 42,489,299 bp[1] End 42,537,573 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F4|9 72.5 cM Start 121,471,782 bp[2] End 121,502,020 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung upper lobe of left lung mucosa of transverse colon rectum mucosa of ileum skin of leg skin of abdomen duodenum right hemisphere of cerebellum minor salivary glands Top expressed in Paneth cell large intestine colon left colon duodenum jejunum ileum granulocyte superior frontal gyrus islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity signal transducer activity G protein-coupled receptor activity protein binding vasoactive intestinal polypeptide receptor activity peptide hormone binding G protein-coupled peptide receptor activity Cellular component plasma membrane membrane integral component of membrane receptor complex integral component of plasma membrane Biological process cell surface receptor signaling pathway positive regulation of cell population proliferation G protein-coupled receptor signaling pathway signal transduction G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7433 22354 Ensembl ENSG00000114812 ENSMUSG00000032528 UniProt P32241 P97751 RefSeq (mRNA) NM_001251882 NM_001251883 NM_001251884 NM_001251885 NM_004624 NM_011703 RefSeq (protein) NP_001238811 NP_001238812 NP_001238813 NP_001238814 NP_004615 NP_035833 Location (UCSC) Chr 3: 42.49 – 42.54 Mb Chr 9: 121.47 – 121.5 Mb PubMed search [3] [4]
Wikidata
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Function

VPAC₁ is a receptor for vasoactive intestinal peptide (VIP), a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase.^[5]

VIP acts in an autocrine fashion via VPAC₁1 to inhibit megakaryocyte proliferation and induce proplatelet formation.^[9][10]

Clinical significance

Patients with idiopathic achalasia show a significant difference in the distribution of SNPs affecting VIPR1.^[11]

VIP and PACAP levels were decreased in anterior vaginal wall of stress urinary incontinence and pelvic organ prolapse patients, they may participate in the pathophysiology of these diseases.^[12]

See also

• Vasoactive intestinal peptide receptor