VNN1

Pantetheinase is an enzyme that in humans is encoded by the VNN1 gene.^[5][6]

VNN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CYF, 4CYG, 4CYY
Identifiers
Aliases	VNN1, HDLCQ8, Tiff66, vanin 1
External IDs	MGI: 108395; HomoloGene: 32130; GeneCards: VNN1; OMA:VNN1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q23.2 Start 132,680,849 bp[1] End 132,714,055 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A4 Start 23,770,586 bp[2] End 23,781,241 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa duodenum gallbladder liver right lobe of liver pancreatic epithelial cell kidney tubule blood pancreatic ductal cell mucosa of ileum Top expressed in jejunum proximal tubule intestinal villus left lung lobe right kidney renal corpuscle human kidney left lobe of liver Ileal epithelium parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity pantetheine hydrolase activity Cellular component integral component of membrane membrane anchored component of membrane extracellular region plasma membrane azurophil granule membrane Biological process positive regulation of T cell differentiation in thymus response to oxidative stress nitrogen compound metabolic process acute inflammatory response negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway innate immune response inflammatory response chronic inflammatory response pantothenate metabolic process neutrophil degranulation cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8876 22361 Ensembl ENSG00000112299 ENSMUSG00000037440 UniProt O95497 Q9Z0K8 RefSeq (mRNA) NM_004666 NM_011704 RefSeq (protein) NP_004657 NP_035834 Location (UCSC) Chr 6: 132.68 – 132.71 Mb Chr 10: 23.77 – 23.78 Mb PubMed search [3] [4]
Wikidata
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This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24.^[6]