VPS24

Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.^[5][6][7]

CHMP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XZE, 3FRT, 3FRV, 2GD5
Identifiers
Aliases	CHMP3, NEDF, VPS24, CGI-149, charged multivesicular body protein 3
External IDs	OMIM: 610052; MGI: 1913950; HomoloGene: 6368; GeneCards: CHMP3; OMA:CHMP3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p11.2 Start 86,503,430 bp[1] End 86,563,479 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 C1|6 32.17 cM Start 71,520,781 bp[2] End 71,559,593 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon secondary oocyte cerebellar vermis nipple skin of hip urethra saphenous vein parotid gland rectum trabecular bone Top expressed in granulocyte dentate gyrus of hippocampal formation granule cell seminal vesicula neural layer of retina superior frontal gyrus right kidney spermatocyte lip muscle of thigh esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phosphatidylcholine binding protein homodimerization activity ubiquitin-specific protease binding identical protein binding Cellular component cytoplasm membrane plasma membrane endosome late endosome membrane extracellular exosome ESCRT III complex cytosol intracellular anatomical structure late endosome cytoplasmic vesicle multivesicular body Biological process autophagosome maturation viral life cycle protein polymerization multivesicular body assembly cell cycle cell division regulation of mitotic spindle assembly endosomal transport regulation of centrosome duplication apoptotic process protein heterooligomerization vacuolar transport septum digestion after cytokinesis protein transport nucleus organization mitotic metaphase plate congression multivesicular body sorting pathway regulation of exosomal secretion macroautophagy multivesicular body-lysosome fusion regulation of early endosome to late endosome transport transport viral budding via host ESCRT complex endosome transport via multivesicular body sorting pathway late endosome to vacuole transport midbody abscission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51652 66700 Ensembl ENSG00000115561 ENSMUSG00000053119 UniProt Q9Y3E7 Q9CQ10 RefSeq (mRNA) NM_001005753 NM_001193517 NM_016079 NM_025783 NM_001355674 NM_001355675 NM_001361405 RefSeq (protein) NP_001005753 NP_001180446 NP_057163 NP_080059 NP_001342603 NP_001342604 NP_001348334 Location (UCSC) Chr 2: 86.5 – 86.56 Mb Chr 6: 71.52 – 71.56 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.^[7]

Interactions

VPS24 has been shown to interact with IGFBP7.^[5]