VPS28

Vacuolar protein sorting-associated protein 28 homolog is a protein that in humans is encoded by the VPS28 gene.^[5]

VPS28
Identifiers
Aliases	VPS28, ESCRT-I subunit, VPS28 subunit of ESCRT-I
External IDs	OMIM: 611952; MGI: 1914164; HomoloGene: 69205; GeneCards: VPS28; OMA:VPS28 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 144,423,601 bp[1] End 144,428,563 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 76,506,287 bp[2] End 76,510,286 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left testis apex of heart right lobe of thyroid gland right ovary left ovary duodenum fundus right testis left lobe of thyroid gland Top expressed in ankle joint facial motor nucleus right lung lobe central gray substance of midbrain vestibular membrane of cochlear duct anterior horn of spinal cord transitional epithelium of urinary bladder nucleus of stria terminalis granulocyte adrenal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-containing complex binding ubiquitin binding protein binding Cellular component cytoplasm cytosol endosome membrane late endosome membrane plasma membrane early endosome endosome membrane extracellular exosome ESCRT I complex host cell Biological process intracellular transport of virus positive regulation of ubiquitin-dependent endocytosis positive regulation of protein catabolic process viral budding via host ESCRT complex viral life cycle multivesicular body assembly endosomal transport negative regulation of protein ubiquitination protein transport ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway macroautophagy transport endosome transport via multivesicular body sorting pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51160 66914 Ensembl ENSG00000160948 ENSG00000285339 ENSMUSG00000115987 UniProt Q9UK41 Q548N1 Q9D1C8 RefSeq (mRNA) NM_016208 NM_183057 NM_025842 NM_001305668 RefSeq (protein) NP_057292 NP_898880 NP_057292.1 NP_001292597 NP_080118 Location (UCSC) Chr 8: 144.42 – 144.43 Mb Chr 15: 76.51 – 76.51 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein involved in endosomal sorting of cell surface receptors via a multivesicular body/late endosome pathway. The encoded protein is one of the three subunits of the ESCRT-I complex (endosomal complexes required for transport) involved in the sorting of ubiquitinated protein. The two other subunits of ESCRT-I are vacuolar protein sorting 23 (VPS23), also known as tumor susceptibility gene 101 (TSG101), and vacuolar protein sorting 37 (VPS37). Two alternative transcripts encoding different isoforms have been described. Additional alternative transcripts may exist but the proteins encoded by these transcripts have not been verified experimentally.^[5]

Interactions

VPS28 has been shown to interact with TSG101.^[6][7][8]