VPS29

VPS29 is a human gene coding for the vacuolar protein sorting protein Vps29, a component of the retromer complex.^[5]

VPS29
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W24, 2R17
Identifiers
Aliases	VPS29, DC15, PEP11, DC7, VPS29 retromer complex component, retromer complex component
External IDs	OMIM: 606932; MGI: 1928344; HomoloGene: 9433; GeneCards: VPS29; OMA:VPS29 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.11 Start 110,491,083 bp[1] End 110,502,111 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 122,492,432 bp[2] End 122,503,047 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte tibialis anterior muscle mucosa of ileum smooth muscle tissue myocardium of left ventricle gastric mucosa rectum cardiac muscle tissue of right atrium right coronary artery tibial arteries Top expressed in otic placode facial motor nucleus saccule barrel cortex yolk sac endocardial cushion endothelial cell of lymphatic vessel atrioventricular valve anterior horn of spinal cord nucleus accumbens More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding zinc ion binding Cellular component late endosome early endosome endosome membrane membrane intracellular membrane-bounded organelle cytoplasm cytosol retromer complex retromer, cargo-selective complex endosome Biological process protein transport Wnt signaling pathway regulation of autophagy intracellular protein transport retrograde transport, endosome to Golgi viral process endocytic recycling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51699 56433 Ensembl ENSG00000111237 ENSMUSG00000029462 UniProt Q9UBQ0 Q05DG7 Q9QZ88 RefSeq (mRNA) NM_001282150 NM_001282151 NM_016226 NM_057180 NM_019780 NM_001347453 NM_001359226 RefSeq (protein) NP_001269079 NP_001269080 NP_057310 NP_476528 NP_001334382 NP_062754 NP_001346155 Location (UCSC) Chr 12: 110.49 – 110.5 Mb Chr 5: 122.49 – 122.5 Mb PubMed search [3] [4]
Wikidata
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Yeast homolog

The homologous protein (one that performs the same function) in yeast is Vacuolar protein sorting 29 homolog (S. cerevisiae).^[6]

Function

VPS29 belongs to a group of genes coding for vacuolar protein sorting (VPS) proteins that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases.^[7] The protein encoded by this gene, Vps29, is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. Vps29 may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment.^[8] Alternative splice variants encoding different isoforms, and usage of multiple polyadenylation sites have been found for this gene.^[6]