VPS33B

Vacuolar protein sorting-associated protein 33B is a protein that in humans is encoded by the VPS33B gene.^[5][6]

VPS33B
Identifiers
Aliases	VPS33B, late endosome and lysosome associated, VPS33B late endosome and lysosome associated
External IDs	OMIM: 608552; MGI: 2446237; HomoloGene: 10261; GeneCards: VPS33B; OMA:VPS33B - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.1 Start 90,998,673 bp[1] End 91,022,603 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 D2 Start 79,919,397 bp[2] End 79,941,502 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell Brodmann area 23 middle temporal gyrus amniotic fluid endothelial cell primary visual cortex gingival epithelium cerebellar hemisphere right hemisphere of cerebellum retinal pigment epithelium Top expressed in secondary oocyte zygote supraoptic nucleus tail of embryo saccule neural layer of retina otic vesicle primary oocyte genital tubercle granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm HOPS complex platelet alpha granule recycling endosome AP-3 adaptor complex endosome late endosome early endosome membrane membrane late endosome membrane clathrin complex lysosomal membrane early endosome perinuclear region of cytoplasm lysosome cytoplasmic vesicle clathrin-coated vesicle Biological process megakaryocyte development endosome to lysosome transport platelet alpha granule organization membrane fusion melanosome localization endosome organization vesicle docking involved in exocytosis autophagosome maturation lysosome localization transport protein transport vesicle-mediated transport regulation of platelet aggregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26276 233405 Ensembl ENSG00000184056 ENSMUSG00000030534 UniProt Q9H267 P59016 RefSeq (mRNA) NM_001289148 NM_001289149 NM_018668 NM_178070 RefSeq (protein) NP_001276077 NP_001276078 NP_061138 NP_835171 Location (UCSC) Chr 15: 91 – 91.02 Mb Chr 7: 79.92 – 79.94 Mb PubMed search [3] [4]
Wikidata
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Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.^[6]