VPS39

hVamp6/Vps39-like protein is a protein that in humans is encoded by the VPS39 gene.^[5][6]

VPS39
Identifiers
Aliases	VPS39, TLP, VAM6, hVam6p, HOPS complex subunit, VPS39 subunit of HOPS complex
External IDs	OMIM: 612188; MGI: 2443189; HomoloGene: 41025; GeneCards: VPS39; OMA:VPS39 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 42,158,701 bp[1] End 42,208,307 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 120,146,942 bp[2] End 120,183,618 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube granulocyte gastric mucosa skin of leg right lobe of thyroid gland skin of abdomen left lobe of thyroid gland anterior pituitary apex of heart right adrenal cortex Top expressed in zygote secondary oocyte primary visual cortex genital tubercle neural layer of retina facial motor nucleus superior frontal gyrus cerebellar cortex motor neuron supraoptic nucleus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 23339 269338 Ensembl ENSG00000166887 ENSMUSG00000027291 UniProt Q96JC1 Q8R5L3 RefSeq (mRNA) NM_001301138 NM_015289 NM_147153 NM_178851 NM_001363053 NM_001363054 RefSeq (protein) NP_001288067 NP_056104 NP_671495 NP_849182 NP_001349982 NP_001349983 Location (UCSC) Chr 15: 42.16 – 42.21 Mb Chr 2: 120.15 – 120.18 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway.^[6]