VPS45

Vacuolar protein sorting-associated protein 45 is a protein that in humans is encoded by the VPS45 gene.^[5][6]

VPS45
Identifiers
Aliases	VPS45, H1, H1SCN5, VPS45A, VPS45B, VPS54A, VSP45, VSP45A, vacuolar protein sorting 45 homolog
External IDs	OMIM: 610035; MGI: 891965; HomoloGene: 5250; GeneCards: VPS45; OMA:VPS45 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.2 Start 150,067,279 bp[1] End 150,145,329 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.1|3 41.65 cM Start 95,907,144 bp[2] End 95,965,778 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum right adrenal cortex ganglionic eminence cerebellar vermis left adrenal gland monocyte left adrenal cortex Achilles tendon Top expressed in neural layer of retina neural tube facial motor nucleus dentate gyrus of hippocampal formation granule cell right kidney muscle of thigh ganglionic eminence Region I of hippocampus proper lens supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component integral component of membrane endosome Golgi apparatus endosome membrane membrane Golgi membrane cellular component synaptic vesicle Biological process protein transport intracellular protein transport blood coagulation vesicle-mediated transport vesicle docking involved in exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11311 22365 Ensembl ENSG00000136631 ENSMUSG00000015747 UniProt Q9NRW7 P97390 RefSeq (mRNA) NM_001279353 NM_001279354 NM_001279355 NM_007259 NM_013841 RefSeq (protein) NP_001266282 NP_001266283 NP_009190 NP_038869 Location (UCSC) Chr 1: 150.07 – 150.15 Mb Chr 3: 95.91 – 95.97 Mb PubMed search [3] [4]
Wikidata
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Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators.^[6]