VPS4A

Vacuolar protein sorting-associated protein 4A is a protein that in humans is encoded by the VPS4A gene.^[5][6][7]

VPS4A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YXR, 2JQ9, 2K3W
Identifiers
Aliases	VPS4A, SKD1, SKD1A, SKD2, VPS4, VPS4-1, vacuolar protein sorting 4 homolog A, CIMDAG
External IDs	OMIM: 609982; MGI: 1890520; HomoloGene: 69132; GeneCards: VPS4A; OMA:VPS4A - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 69,311,350 bp[1] End 69,326,939 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 107,757,854 bp[2] End 107,772,387 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle cerebellar vermis muscle of thigh Skeletal muscle tissue of rectus abdominis parotid gland apex of heart Brodmann area 23 middle temporal gyrus right frontal lobe endothelial cell Top expressed in spermatid spermatocyte seminiferous tubule neural layer of retina dentate gyrus of hippocampal formation granule cell dorsal tegmental nucleus superior colliculus pontine nuclei medial dorsal nucleus primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein domain specific binding microtubule-severing ATPase activity protein C-terminus binding protein binding hydrolase activity ATP binding ATPase activity protein-containing complex binding Cellular component cytoplasm ESCRT III complex cytosol endosome late endosome centrosome spindle pole vacuolar membrane late endosome membrane Flemming body membrane plasma membrane midbody early endosome perinuclear region of cytoplasm lysosome extracellular exosome nucleus endosome membrane Biological process late endosomal microautophagy endosomal vesicle fusion viral release from host cell abscission viral budding via host ESCRT complex nucleus organization viral life cycle multivesicular body assembly vacuole organization vesicle uncoating regulation of protein localization cell division intracellular cholesterol transport ESCRT complex disassembly vesicle budding from membrane ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway transport protein transport positive regulation of viral life cycle ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway cell cycle negative regulation of cytokinesis septum digestion after cytokinesis mitotic metaphase plate congression positive regulation of exosomal secretion vesicle-mediated transport regulation of protein localization to plasma membrane ESCRT III complex disassembly cytoplasmic microtubule organization endosomal transport macroautophagy positive regulation of viral budding via host ESCRT complex actomyosin contractile ring contraction protein targeting to lysosome nuclear envelope organization nuclear membrane reassembly mitotic cytokinesis checkpoint signaling cytoskeleton-dependent cytokinesis midbody abscission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27183 116733 Ensembl ENSG00000132612 ENSMUSG00000031913 UniProt Q9UN37 Q8VEJ9 RefSeq (mRNA) NM_013245 NM_126165 RefSeq (protein) NP_037377 NP_037377.1 NP_569053 Location (UCSC) Chr 16: 69.31 – 69.33 Mb Chr 8: 107.76 – 107.77 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. They share a high degree of amino acid sequence similarity with each other, and also with yeast Vps4 and mouse proteins. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.^[7]

Interactions

VPS4A has been shown to interact with CHMP1A.^[8]