VRK1

Serine/threonine-protein kinase VRK1 is an enzyme that in humans is encoded by the VRK1 gene.^[5][6]

VRK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KTY, 2KUL, 2LAV, 2RSV, 3OP5
Identifiers
Aliases	VRK1, PCH1, PCH1A, vaccinia related kinase 1, VRK serine/threonine kinase 1
External IDs	OMIM: 602168; MGI: 1261847; HomoloGene: 2541; GeneCards: VRK1; OMA:VRK1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.2 Start 96,797,304 bp[1] End 96,954,846 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E-F1 Start 106,010,228 bp[2] End 106,077,426 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte bone marrow secondary oocyte ganglionic eminence left testis ventricular zone right testis trabecular bone testicle gonad Top expressed in granulocyte tail of embryo genital tubercle ganglionic eminence epiblast primitive streak ventricular zone abdominal wall embryo secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein serine/threonine kinase activity protein binding histone kinase activity (H3-T3 specific) histone kinase activity (H3-S10 specific) ATP binding protein kinase binding Cellular component spindle nucleoplasm nucleolus Golgi stack cytoskeleton nucleus cytoplasm cytosol Biological process phosphorylation cell division protein phosphorylation mitotic nuclear membrane disassembly cell cycle mitotic nuclear membrane reassembly Golgi disassembly regulation of cell shape protein autophosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7443 22367 Ensembl ENSG00000100749 ENSMUSG00000021115 UniProt Q99986 Q80X41 RefSeq (mRNA) NM_003384 NM_001029843 NM_001029844 NM_011705 NM_001364365 NM_001364367 NM_001364368 RefSeq (protein) NP_003375 NP_001025014 NP_001025015 NP_035835 NP_001351294 NP_001351296 NP_001351297 Location (UCSC) Chr 14: 96.8 – 96.95 Mb Chr 12: 106.01 – 106.08 Mb PubMed search [3] [4]
Wikidata
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Cartoon diagram of the Human vaccinia-related kinase protein PDB entry 6bru

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and C-jun.^[6]