VWA2

von Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen (AMACO), is a protein that in humans is encoded by the VWA2 gene.^[5][6]

VWA2
Identifiers
Aliases	VWA2, AMACO, CCSP-2, NET42, von Willebrand factor A domain containing 2, CCSP2
External IDs	OMIM: 618281; MGI: 2684334; HomoloGene: 18238; GeneCards: VWA2; OMA:VWA2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.3 Start 114,239,254 bp[1] End 114,294,489 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 D2 Start 56,862,681 bp[2] End 56,900,510 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus right uterine tube olfactory zone of nasal mucosa sural nerve testicle body of stomach fundus skin of abdomen body of pancreas skin of leg Top expressed in otic vesicle molar secondary oocyte primary oocyte lip tail of embryo proximal tubule genital tubercle cervix pulmonary alveolar epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding identical protein binding calcium ion binding Cellular component extracellular region basement membrane extracellular exosome extracellular space extracellular matrix collagen-containing extracellular matrix Biological process calcium-independent cell-matrix adhesion protein homooligomerization regulation of insulin receptor signaling pathway growth plate cartilage chondrocyte morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 340706 240675 Ensembl ENSG00000165816 ENSMUSG00000025082 UniProt Q5GFL6 Q70UZ7 RefSeq (mRNA) NM_001272046 NM_198496 NM_001320804 NM_172840 RefSeq (protein) NP_001258975 NP_001307733 NP_766428 Location (UCSC) Chr 10: 114.24 – 114.29 Mb Chr 19: 56.86 – 56.9 Mb PubMed search [3] [4]
Wikidata
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AMACO is a member of the von Willebrand factor A-like (VWA) domain containing protein superfamily and consists of three VWA-like domains, two EGF-like domains, a cysteine-rich domain and a unique C-terminal domain.^[6] AMACO is an extracellular matrix protein and mostly deposited adjacent to basement membranes.^[7]

AMACO binds directly to FRAS1 which is part of the Fraser complex important for epithelial-connective tissue interaction,^[8] the exact biological role of AMACO, however, is still unknown. In 2005 AMACO was found markedly induced in colon cancers;^[9] indicating that it might be a good candidate as a biomarker for this type of cancer.