Vac7

Vacuolar segregation protein 7 is a protein that in yeast is encoded by the VAC7 gene. VAC7 is a component of the PI(3,5)P2 regulatory complex, composed of ATG18, FIG4, FAB1, VAC14 and VAC7.

Vacuolar segregation protein 7
Identifiers
Organism	S. cerevisiae S288c
Symbol	VAC7
Entrez	855673
RefSeq (mRNA)	NM_001182893
RefSeq (Prot)	NP_014344
UniProt	P53950
Other data
Chromosome	XIV: 0.53 - 0.53 Mb
Search for Structures Swiss-model Domains InterPro

Function

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). VAC7 activates FAB1 kinase for example during hyperosmotic shock and can elevate levels of PtdIns(3,5)P2 in the absence of VAC14 and FIG4. VAC7 is directly involved in vacuolar membrane scission and is required for normal vacuole acidification, inheritance and morphology.^{[1][2][3][4][5]}