Vasodilator-stimulated phosphoprotein

Vasodilator-stimulated phosphoprotein is a protein that in humans is encoded by the VASP gene.^[5][6]

VASP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EGX, 1USD, 1USE, 2PAV, 2PBD, 3CHW
Identifiers
Aliases	VASP, vasodilator-stimulated phosphoprotein, vasodilator stimulated phosphoprotein
External IDs	OMIM: 601703; MGI: 109268; HomoloGene: 7592; GeneCards: VASP; OMA:VASP - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 45,506,579 bp[1] End 45,526,983 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 18,990,854 bp[2] End 19,005,742 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte mucosa of transverse colon saphenous vein spleen blood muscle layer of sigmoid colon rectum thoracic aorta ascending aorta Top expressed in granulocyte mesenteric lymph nodes tibiofemoral joint colon spleen left colon left lung lobe pyloric antrum epithelium of stomach atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function profilin binding SH3 domain binding protein binding actin binding cadherin binding Cellular component cell projection membrane focal adhesion bicellular tight junction filopodium plasma membrane cell junction actin cytoskeleton extracellular exosome cytoskeleton lamellipodium membrane lamellipodium filopodium membrane cytoplasm cytosol Biological process positive regulation of actin filament polymerization axon guidance neural tube closure actin polymerization or depolymerization protein homotetramerization actin cytoskeleton organization cell junction assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7408 22323 Ensembl ENSG00000125753 ENSMUSG00000030403 UniProt P50552 P70460 RefSeq (mRNA) NM_001008736 NM_003370 NM_001282021 NM_001282022 NM_009499 RefSeq (protein) NP_003361 NP_001268950 NP_001268951 NP_033525 Location (UCSC) Chr 19: 45.51 – 45.53 Mb Chr 7: 18.99 – 19.01 Mb PubMed search [3] [4]
Wikidata
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Function

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an N-terminal EVH1 domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions cell membranes. In the mid-region of the protein, family members have a proline-rich region that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.^[6]

Interactions

Vasodilator-stimulated phosphoprotein has been shown to interact with Zyxin,^[7][8] Profilin 1,^[7] and PFN2.^[7][9]