Vedaclidine

Vedaclidine
Clinical data
Other names	(S)-3-[4-(butylthio)-1,2,5-thiadiazol-3-yl]quinuclidine
Routes of; administration	oral
ATC code	None;
Identifiers
	IUPAC name (3S)-3-[4-(Butylsulfanyl)-1,2,5-thiadiazol-3-yl]quinuclidine;
CAS Number	141575-50-0;
PubChem CID	9889093;
ChemSpider	8064764;
UNII	98IW5HAV1N;
ChEMBL	ChEMBL136807;
CompTox Dashboard (EPA)	DTXSID30275663 ;
Chemical and physical data
Formula	C13H21N3S2
Molar mass	283.45 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCSC1=NSN=C1[C@@H]2CN3CCC2CC3;
	InChI InChI=1S/C13H21N3S2/c1-2-3-8-17-13-12(14-18-15-13)11-9-16-6-4-10(11)5-7-16/h10-11H,2-9H2,1H3/t11-/m1/s1; Key:WZZPXVURFDJHGI-LLVKDONJSA-N;

Vedaclidine (INN,^[1]^: 180 codenamed LY-297,802, NNC 11-1053) is an experimental analgesic drug which acts as a mixed agonist–antagonist at muscarinic acetylcholine receptors, being a potent and selective agonist for the M₁ and M₄ subtypes, yet an antagonist at the M₂, M₃ and M₅ subtypes.^[2]^[3] It is orally active and an effective analgesic over 3× the potency of morphine, with side effects such as salivation and tremor only occurring at many times the effective analgesic dose.^[4]^[5]^[6] Human trials showed little potential for development of dependence or abuse,^[7] and research is continuing into possible clinical application in the treatment of neuropathic pain and cancer pain relief.^[8]

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Vedaclidine

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References

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