WASF2

Wiskott–Aldrich syndrome protein family member 2 is a protein that in humans is encoded by the WASF2 gene.^[5]

WASF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2A40
Identifiers
Aliases	WASF2, IMD2, SCAR2, WASF4, WAVE2, dJ393P12.2, WAS protein family member 2, WASP family member 2
External IDs	OMIM: 605875; MGI: 1098641; HomoloGene: 86743; GeneCards: WASF2; OMA:WASF2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 27,404,230 bp[1] End 27,490,167 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.3|4 66.22 cM Start 132,857,816 bp[2] End 132,927,067 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple skin of arm tendon of biceps brachii saphenous vein pylorus lower lobe of lung cardia mucosa of pharynx trachea lactiferous duct Top expressed in zygote left lung lobe tibiofemoral joint secondary oocyte vas deferens gastrula Gonadal ridge mesenteric lymph nodes submandibular gland decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-containing complex binding protein binding actin binding SH3 domain binding cadherin binding protein kinase A binding Cellular component cytoplasm cytosol cell projection SCAR complex cell-cell junction ruffle intracellular anatomical structure early endosome actin cytoskeleton extracellular exosome cytoskeleton lamellipodium protein-containing complex synapse Biological process megakaryocyte development endocytosis Fc-gamma receptor signaling pathway involved in phagocytosis adenylate cyclase-modulating G protein-coupled receptor signaling pathway actin filament-based movement vascular endothelial growth factor receptor signaling pathway angiogenesis Rac protein signal transduction viral process positive regulation of lamellipodium assembly negative regulation of stress fiber assembly ameboidal-type cell migration lamellipodium morphogenesis actin cytoskeleton organization lamellipodium assembly postsynaptic actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10163 242687 Ensembl ENSG00000158195 ENSMUSG00000028868 UniProt Q9Y6W5 Q8BH43 RefSeq (mRNA) NM_006990 NM_001201404 NM_153423 RefSeq (protein) NP_001188333 NP_008921 NP_700472 Location (UCSC) Chr 1: 27.4 – 27.49 Mb Chr 4: 132.86 – 132.93 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the Wiskott–Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location^[6] has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X.^[7]

Interactions

WASF2 has been shown to interact with BAIAP2.^[8]