WDR26

WD repeat-containing protein 26 is a protein that in humans is encoded by the WDR26 gene.^[5]

WDR26
Identifiers
Aliases	WDR26, CDW2, GID7, MIP2, WD repeat domain 26, SKDEAS
External IDs	OMIM: 617424; MGI: 1923825; HomoloGene: 11857; GeneCards: WDR26; OMA:WDR26 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.11-q42.12 Start 224,385,146 bp[1] End 224,437,033 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H4 Start 181,000,793 bp[2] End 181,039,566 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte mucosa of pharynx epithelium of colon bone marrow cell stromal cell of endometrium trabecular bone oral cavity skin of thigh amniotic fluid Top expressed in aortic valve ascending aorta human fetus Rostral migratory stream blood tibiofemoral joint parotid gland left lung lobe skin of external ear epithelium of lens More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 80232 226757 Ensembl ENSG00000162923 ENSMUSG00000038733 UniProt Q9H7D7 Q8C6G8 RefSeq (mRNA) NM_001115113 NM_025160 NM_001379403 NM_145514 RefSeq (protein) NP_001108585 NP_079436 NP_001366332 NP_663489 NP_001390510 NP_001390511 NP_001390512 NP_001390513 NP_001390514 NP_001390515 NP_001390516 NP_001390517 NP_001390518 Location (UCSC) Chr 1: 224.39 – 224.44 Mb Chr 1: 181 – 181.04 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.^[5]

Clinical significance

Pathogenic variants of the gene cause Skraban–Deardorff syndrome.^[6]