WDR36

WD repeat-containing protein 36 is a protein that in humans is encoded by the WDR36 gene.^[5][6][7]

WDR36
Identifiers
Aliases	WDR36, GLC1G, TA-WDRP, TAWDRP, UTP21, WD repeat domain 36
External IDs	OMIM: 609669; MGI: 1917819; HomoloGene: 6536; GeneCards: WDR36; OMA:WDR36 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q22.1 Start 111,092,321 bp[1] End 111,130,502 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 32,970,278 bp[2] End 33,000,647 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tibialis anterior muscle deltoid muscle skin of arm pancreatic epithelial cell testicle parietal pleura germinal epithelium gonad mucosa of ileum Top expressed in primary oocyte epiblast lumbar spinal ganglion primitive streak secondary oocyte spermatocyte endothelial cell of lymphatic vessel embryo morula abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding Cellular component nucleolus nucleus nucleoplasm small-subunit processome Pwp2p-containing subcomplex of 90S preribosome Biological process retina homeostasis regulation of axon extension ribosome biogenesis response to stimulus visual perception rRNA processing biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 134430 225348 Ensembl ENSG00000134987 ENSMUSG00000038299 UniProt Q8NI36 n/a RefSeq (mRNA) NM_139281 NM_001110015 NM_001110016 NM_144863 RefSeq (protein) NP_644810 n/a Location (UCSC) Chr 5: 111.09 – 111.13 Mb Chr 18: 32.97 – 33 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG).^[7]