WDR45L

WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3), also known as WD repeat-containing protein 45-like is a protein that in humans is encoded by the gene.^[5]

WDR45B
Identifiers
Aliases	WDR45B, WDR45L, WIPI-3, WIPI3, WD repeat domain 45B, NEDSBAS
External IDs	OMIM: 609226; MGI: 1914090; HomoloGene: 6028; GeneCards: WDR45B; OMA:WDR45B - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 82,614,562 bp[1] End 82,648,553 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E2|11 85.24 cM Start 121,218,050 bp[2] End 121,245,271 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte epithelium of nasopharynx beta cell right uterine tube mucosa of pharynx nasal epithelium gingival epithelium epithelium of bronchus skin of arm bronchial epithelial cell Top expressed in epiblast neural tube ovary mesencephalon placenta dentate gyrus of hippocampal formation granule cell granulocyte ventricular zone ganglionic eminence heart More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatidylinositol-3-phosphate binding phosphatidylinositol-3,5-bisphosphate binding protein binding TSC1-TSC2 complex binding lipid binding Cellular component cytosol extrinsic component of membrane phagophore assembly site membrane phagophore assembly site lysosome Biological process protein lipidation protein localization to phagophore assembly site autophagy of mitochondrion autophagy of nucleus autophagosome assembly cellular response to starvation autophagy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56270 66840 Ensembl ENSG00000141580 ENSMUSG00000025173 UniProt Q5MNZ6 Q9CR39 RefSeq (mRNA) NM_019613 NM_025793 RefSeq (protein) NP_062559 NP_080069 Location (UCSC) Chr 17: 82.61 – 82.65 Mb Chr 11: 121.22 – 121.25 Mb PubMed search [3] [4]
Wikidata
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Structure and function

WIPI-3 is a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein–protein interactions, and a conserved motif for interaction with phospholipids.^[5]

See also

• WIPI protein family