WDR57

WD repeat domain 57 (U5 snRNP specific), also known as WDR57, is a gene found in many organisms, including, but not limited to Homo sapiens, Gallus gallus, Pan troglodytes, Canus familiaris, Bos taurus, Mus musculus, and Rattus norvegicus.^[5]

SNRNP40
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JCR
Identifiers
Aliases	SNRNP40, 40K, HPRP8BP, PRP8BP, PRPF8BP, SPF38, WDR57, small nuclear ribonucleoprotein U5 subunit 40
External IDs	OMIM: 607797; MGI: 1913835; HomoloGene: 3538; GeneCards: SNRNP40; OMA:SNRNP40 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.2 Start 31,259,568 bp[1] End 31,296,788 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 130,253,925 bp[2] End 130,283,819 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone mucosa of transverse colon cerebellar hemisphere C1 segment anterior pituitary right hemisphere of cerebellum ectocervix right ovary tibial nerve Top expressed in epiblast ventricular zone genital tubercle tail of embryo ganglionic eminence embryo embryo neural tube mesencephalon bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component sno(s)RNA-containing ribonucleoprotein complex U5 snRNP catalytic step 2 spliceosome spliceosomal complex precatalytic spliceosome nucleus nucleoplasm cytosol nuclear speck U2-type catalytic step 2 spliceosome Biological process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome mRNA processing RNA processing RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9410 66585 Ensembl ENSG00000060688 ENSMUSG00000074088 UniProt Q96DI7 Q6PE01 RefSeq (mRNA) NM_004814 NM_025645 RefSeq (protein) NP_004805 NP_079921 Location (UCSC) Chr 1: 31.26 – 31.3 Mb Chr 4: 130.25 – 130.28 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs.^[5]

Interactions

WDR57 has been shown to interact with PRPF8^[6][7] and EFTUD2.^[6][7]