WDR6

WD repeat-containing protein 6 is a protein that in humans is encoded by the WDR6 gene.^[5]

WDR6
Identifiers
Aliases	WDR6, WD repeat domain 6, Trm734
External IDs	OMIM: 606031; MGI: 1930140; HomoloGene: 117682; GeneCards: WDR6; OMA:WDR6 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 49,007,062 bp[1] End 49,015,953 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F2 Start 108,449,510 bp[2] End 108,455,938 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube pituitary gland anterior pituitary right lobe of thyroid gland left lobe of thyroid gland left ovary right ovary tendon of biceps brachii canal of the cervix body of uterus Top expressed in arcuate nucleus ventromedial nucleus median eminence paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus mammillary body lateral hypothalamus anterior amygdaloid area lateral septal nucleus ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component cytoplasm COP9 signalosome cytosol plasma membrane Biological process cell cycle negative regulation of autophagy negative regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11180 83669 Ensembl ENSG00000178252 ENSMUSG00000066357 UniProt Q9NNW5 Q99ME2 RefSeq (mRNA) NM_018031 NM_001320546 NM_001320547 NM_031392 RefSeq (protein) NP_001307475 NP_001307476 NP_060501 NP_113569 Location (UCSC) Chr 3: 49.01 – 49.02 Mb Chr 9: 108.45 – 108.46 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is ubiquitously expressed in adult and fetal tissues.^[5]