WD repeat-containing protein 11

WD repeat-containing protein 11 (WDR11) also known as bromodomain and WD repeat-containing protein 2 (BRWD2) is a protein that in humans is encoded by the WDR11 gene.^[5][6][7]

WDR11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MB3
Identifiers
Aliases	WDR11, BRWD2, DR11, HH14, WDR15, SRI1, WD repeat domain 11
External IDs	OMIM: 606417; MGI: 1920230; HomoloGene: 41229; GeneCards: WDR11; OMA:WDR11 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.12 Start 120,851,305 bp[1] End 120,909,524 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 129,193,587 bp[2] End 129,237,462 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx Achilles tendon Epithelium of choroid plexus germinal epithelium oocyte visceral pleura monocyte secondary oocyte right uterine tube parietal pleura Top expressed in retinal pigment epithelium ciliary body Paneth cell superior cervical ganglion medullary collecting duct renal corpuscle hand otolith organ utricle interventricular septum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component lysosomal membrane nucleus microtubule cytoskeleton integral component of membrane cytoplasm membrane cytosol Golgi apparatus trans-Golgi network cytoskeleton axoneme cytoplasmic vesicle ciliary basal body cell projection Biological process intracellular protein transport heart development regulation of smoothened signaling pathway multicellular organism growth cilium assembly head development vesicle tethering to Golgi Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55717 207425 Ensembl ENSG00000120008 ENSMUSG00000042055 UniProt Q9BZH6 Q8K1X1 RefSeq (mRNA) NM_018117 NM_172255 RefSeq (protein) NP_060587 NP_758459 Location (UCSC) Chr 10: 120.85 – 120.91 Mb Chr 7: 129.19 – 129.24 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. WDR11 has been shown to be part of a trimer with FAM91A1 (Family With Sequence Similarity 91 Member A1) and C17orf75, as elicited through immunoprecipitation, fractionation, and mass spectrometry. This trimer has been proposed to promote the Golgi’s capture of vesicles.^[8] Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.^[7]

Clinical significance

This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.^[7]