WFDC5

WAP four-disulfide core domain protein 5 is a protein that in humans is encoded by the WFDC5 gene.^[5][6][7]

WFDC5
Identifiers
Aliases	WFDC5, PRG5, WAP1, dJ211D12.5, WAP four-disulfide core domain 5
External IDs	OMIM: 605161; MGI: 2384800; HomoloGene: 17072; GeneCards: WFDC5; OMA:WFDC5 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 45,109,452 bp[1] End 45,115,172 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 164,018,247 bp[2] End 164,024,662 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm skin of abdomen skin of leg skin of thigh nipple human penis skin of hip vulva testicle gingival epithelium Top expressed in esophagus lip skin of external ear skin of back skin of abdomen cervix umbilical cord gastrula stomach epidermis More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase inhibitor activity serine-type endopeptidase inhibitor activity Cellular component extracellular region Biological process negative regulation of endopeptidase activity negative regulation of peptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 149708 209232 Ensembl ENSG00000175121 ENSMUSG00000040154 UniProt Q8TCV5 n/a RefSeq (mRNA) NM_145652 NM_001395506 NM_145369 RefSeq (protein) NP_663627 n/a Location (UCSC) Chr 20: 45.11 – 45.12 Mb Chr 2: 164.02 – 164.02 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.^[7]