WFIKKN1

WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 is a protein that is encoded by the WFIKKN1 gene.^[5][6][7] when found in humans.

WFIKKN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DDI, 2DDJ
Identifiers
Aliases	WFIKKN1, C16orf12, RJD2, WFDC20A, WFIKKN, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
External IDs	OMIM: 608021; MGI: 2670967; HomoloGene: 14244; GeneCards: WFIKKN1; OMA:WFIKKN1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 629,239 bp[1] End 634,117 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 26,096,602 bp[2] End 26,099,832 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum mucosa of transverse colon right frontal lobe pituitary gland putamen Brodmann area 9 anterior cingulate cortex anterior pituitary nucleus accumbens skin of abdomen Top expressed in otic vesicle primitive streak embryo somite morula tail of embryo granulocyte embryo blastocyst yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity enzyme inhibitor activity protein binding metalloendopeptidase inhibitor activity serine-type endopeptidase inhibitor activity receptor antagonist activity transforming growth factor beta binding Cellular component extracellular region Biological process skeletal system development negative regulation of DNA binding roof of mouth development negative regulation of peptidase activity negative regulation of protein binding negative regulation of endopeptidase activity negative regulation of transforming growth factor beta receptor signaling pathway extracellular negative regulation of signal transduction negative regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117166 215001 Ensembl ENSG00000127578 ENSMUSG00000071192 UniProt Q96NZ8 Q8R0S6 RefSeq (mRNA) NM_053284 NM_001100454 RefSeq (protein) NP_444514 NP_001093924 Location (UCSC) Chr 16: 0.63 – 0.63 Mb Chr 17: 26.1 – 26.1 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases.^[7]