WIPF2

WAS/WASL-interacting protein family member 2 is a protein that in humans is encoded by the WIPF2 gene.^[5][6][7]

WIPF2
Identifiers
Aliases	WIPF2, WICH, WIRE, WAS/WASL interacting protein family member 2
External IDs	OMIM: 609692; MGI: 1924462; HomoloGene: 15777; GeneCards: WIPF2; OMA:WIPF2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 40,219,304 bp[1] End 40,284,136 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 98,754,464 bp[2] End 98,795,866 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte buccal mucosa cell frontal pole lower lobe of lung nipple Brodmann area 46 internal globus pallidus Brodmann area 10 optic nerve paraflocculus of cerebellum Top expressed in transitional epithelium of urinary bladder genital tubercle subiculum superior colliculus ventral tegmental area tail of embryo central gray substance of midbrain medial geniculate nucleus Region I of hippocampus proper dorsomedial hypothalamic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function actin binding protein binding actin filament binding Cellular component cytoplasm cytosol cytoskeleton nucleoplasm plasma membrane actin filament actin cortical patch Biological process Fc-gamma receptor signaling pathway involved in phagocytosis actin cortical patch assembly endocytosis actin filament-based movement positive regulation of actin nucleation actin cortical patch localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 147179 68524 Ensembl ENSG00000171475 ENSMUSG00000038013 UniProt Q8TF74 Q6PEV3 RefSeq (mRNA) NM_133264 NM_197940 RefSeq (protein) NP_573571 NP_922922 Location (UCSC) Chr 17: 40.22 – 40.28 Mb Chr 11: 98.75 – 98.8 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery.^[7]