WIPI1

WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also known as Atg18 protein homolog (ATG18) and WD40 repeat protein interacting with phosphoinositides of 49 kDa (WIPI 49 kDa), is a protein that in humans is encoded by the WIPI1 gene.^[5][6][7]

WIPI1
Identifiers
Aliases	WIPI1, ATG18, ATG18A, WIPI49, WD repeat domain, phosphoinositide interacting 1
External IDs	OMIM: 609224; MGI: 1261864; HomoloGene: 117983; GeneCards: WIPI1; OMA:WIPI1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q24.2 Start 68,420,948 bp[1] End 68,457,513 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 72.18 cM Start 109,464,157 bp[2] End 109,502,793 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium sperm gastrocnemius muscle minor salivary glands muscle of thigh biceps brachii left ventricle skeletal muscle tissue sural nerve olfactory zone of nasal mucosa Top expressed in seminal vesicula interventricular septum saccule retinal pigment epithelium muscle of thigh right ventricle stroma of bone marrow submandibular gland otic vesicle granulocyte More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatidylinositol-3-phosphate binding phosphatidylinositol-3,5-bisphosphate binding androgen receptor binding signaling receptor binding estrogen receptor binding protein binding lipid binding Cellular component cytoplasm phagophore assembly site membrane endosome Golgi apparatus membrane Golgi membrane trans-Golgi network autophagosome membrane endosome membrane cytoskeleton cytoplasmic vesicle clathrin-coated vesicle phagophore assembly site cytosol extrinsic component of membrane Biological process vesicle targeting, trans-Golgi to endosome autophagy IRE1-mediated unfolded protein response macroautophagy autophagy of mitochondrion protein lipidation protein localization to phagophore assembly site autophagy of nucleus autophagosome assembly cellular response to starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55062 52639 Ensembl ENSG00000070540 ENSMUSG00000041895 UniProt Q5MNZ9 Q8R3E3 RefSeq (mRNA) NM_017983 NM_001320772 NM_145940 RefSeq (protein) NP_001307701 NP_060453 NP_666052 Location (UCSC) Chr 17: 68.42 – 68.46 Mb Chr 11: 109.46 – 109.5 Mb PubMed search [3] [4]
Wikidata
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Structure and function

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein–protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids.^[5][7]

See also

• WIPI protein family