WNK3

Serine/threonine-protein kinase WNK3, also known as protein kinase lysine-deficient 3, is a protein that in humans is encoded by the WNK3 gene.^[5]

WNK3
Identifiers
Aliases	WNK3, PRKWNK lysine deficient protein kinase 3
External IDs	OMIM: 300358; MGI: 2652875; HomoloGene: 32493; GeneCards: WNK3; OMA:WNK3 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.22 Start 54,192,823 bp[1] End 54,358,642 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F3 Start 149,981,074 bp[2] End 150,103,148 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis buccal mucosa cell tail of epididymis testicle gonad caput epididymis secondary oocyte seminal vesicula internal globus pallidus retinal pigment epithelium Top expressed in hand lateral hypothalamus lumbar subsegment of spinal cord ventromedial nucleus paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus anterior amygdaloid area tail of embryo mammillary body lateral septal nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding kinase activity protein serine/threonine kinase activity protein binding chloride channel inhibitor activity ATP binding potassium channel inhibitor activity Cellular component cytoplasm bicellular tight junction adherens junction cytosol Biological process phosphorylation negative regulation of apoptotic process protein phosphorylation positive regulation of ion transmembrane transporter activity positive regulation of peptidyl-threonine phosphorylation positive regulation of sodium ion transport protein autophosphorylation positive regulation of sodium ion transmembrane transporter activity negative regulation of pancreatic juice secretion positive regulation of calcium ion transport intracellular signal transduction regulation of calcium ion import protein localization to plasma membrane positive regulation of protein localization to plasma membrane ion homeostasis negative regulation of sodium ion transport positive regulation of potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65267 279561 Ensembl ENSG00000196632 ENSMUSG00000041245 UniProt Q9BYP7 Q80XP9 RefSeq (mRNA) NM_001002838 NM_020922 NM_001395166 NM_001271678 NM_001271679 RefSeq (protein) NP_001002838 NP_065973 NP_001258607 NP_001258608 Location (UCSC) Chr X: 54.19 – 54.36 Mb Chr X: 149.98 – 150.1 Mb PubMed search [3] [4]
Wikidata
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Function

WNK3 is a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca²⁺ transport pathway, and it plays a role in the increase of cell survival in a caspase 3 dependent pathway.^[5]