WNT10B

Protein Wnt-10b (formerly Wnt12^[5]) is a protein that in humans is encoded by the WNT10B gene.^[6][7][8][9]

WNT10B
Identifiers
Aliases	WNT10B, SHFM6, WNT-12, Wnt family member 10B, STHAG8
External IDs	OMIM: 601906; MGI: 108061; HomoloGene: 20721; GeneCards: WNT10B; OMA:WNT10B - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 48,965,340 bp[1] End 48,971,735 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F1|15 54.65 cM Start 98,668,593 bp[2] End 98,676,031 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in orbitofrontal cortex nucleus accumbens Brodmann area 10 Region I of hippocampus proper cingulate gyrus anterior cingulate cortex Brodmann area 46 right frontal lobe dorsolateral prefrontal cortex entorhinal cortex Top expressed in prostatic epithelium surface ectoderm inner root sheath enamel knot hair skin of finger lip inner cell mass morula pretectal area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function receptor ligand activity frizzled binding signaling receptor binding Cellular component extracellular region extracellular space Biological process cellular response to organic substance myoblast differentiation involved in skeletal muscle regeneration cellular response to retinoic acid cell fate commitment negative regulation of fat cell differentiation positive regulation of RNA polymerase II transcription preinitiation complex assembly chondrocyte differentiation positive regulation of bone mineralization lipid metabolism positive regulation of canonical Wnt signaling pathway regulation of transcription by RNA polymerase II hematopoietic stem cell proliferation cellular response to organic cyclic compound protein stabilization positive regulation of DNA-binding transcription factor activity positive regulation of ossification negative regulation of transcription by RNA polymerase II bone trabecula formation positive regulation of timing of anagen regulation of fat cell differentiation multicellular organism development positive regulation of epithelial cell differentiation positive regulation of osteoblast differentiation fungiform papilla development skeletal muscle tissue regeneration G2/M transition of mitotic cell cycle skeletal muscle fiber development neuron differentiation positive regulation of cell population proliferation negative regulation of epithelial cell proliferation positive regulation of apoptotic process regulation of proteasomal ubiquitin-dependent protein catabolic process canonical Wnt signaling pathway regulation of skeletal muscle tissue development positive regulation of G2/M transition of mitotic cell cycle smoothened signaling pathway cellular response to parathyroid hormone stimulus regulation of protein metabolic process sensory perception of taste cellular response to cAMP positive regulation of transcription by RNA polymerase II Wnt signaling pathway regulation of signaling receptor activity negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7480 22410 Ensembl ENSG00000169884 ENSMUSG00000022996 UniProt O00744 P48614 RefSeq (mRNA) NM_003394 NM_011718 RefSeq (protein) NP_003385 NP_035848 Location (UCSC) Chr 12: 48.97 – 48.97 Mb Chr 15: 98.67 – 98.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.

This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is, it is presumed, a molecular switch that governs adipogenesis. Gain-of-function of Wnt10b in mouse hearts has shown to improve cardiac tissue repair after myocardial injury, by promoting coronary vessel formation and attenuating pathological fibrosis.^[10] This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.^[9]