WTAP (gene)

Pre-mRNA-splicing regulator WTAP is a protein that in humans is encoded by the WTAP gene.^[5][6][7]

WTAP
Identifiers
Aliases	WTAP, Mum2, Wilms tumor 1 associated protein, WT1 associated protein
External IDs	OMIM: 605442; MGI: 1926395; HomoloGene: 68422; GeneCards: WTAP; OMA:WTAP - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.3 Start 159,725,585 bp[1] End 159,756,319 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A1 Start 13,185,683 bp[2] End 13,213,056 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte epithelium of nasopharynx vena cava buccal mucosa cell cartilage tissue amniotic fluid germinal epithelium pericardium parietal pleura caput epididymis Top expressed in morula ciliary body medullary collecting duct vestibular membrane of cochlear duct retinal pigment epithelium endothelial cell of lymphatic vessel condyle primary oocyte fossa genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component nuclear membrane nucleus RNA N6-methyladenosine methyltransferase complex nuclear speck nucleoplasm cytoplasm Biological process RNA splicing cell cycle mRNA processing mRNA methylation regulation of alternative mRNA splicing, via spliceosome multicellular organism development RNA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9589 60532 Ensembl ENSG00000146457 ENSMUSG00000060475 UniProt Q15007 Q9ER69 RefSeq (mRNA) NM_001270531 NM_001270532 NM_001270533 NM_004906 NM_152857 NM_152858 NM_001113532 NM_001113533 NM_175394 NM_001379058 RefSeq (protein) NP_001257460 NP_001257461 NP_001257462 NP_004897 NP_690596 NP_690597 NP_001107004 NP_001107005 NP_780603 NP_001365987 Location (UCSC) Chr 6: 159.73 – 159.76 Mb Chr 17: 13.19 – 13.21 Mb PubMed search [3] [4]
Wikidata
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The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform.^[7]

Interactions

WTAP has been shown to interact with WT1.^[6]