WWOX

WW domain-containing oxidoreductase is an enzyme that in humans is encoded by the WWOX gene.^[5][6][7][8]

WWOX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WMV
Identifiers
Aliases	WWOX, D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SCAR12, SDR41C1, WOX1, EIEE28, WW domain containing oxidoreductase, DEE28
External IDs	OMIM: 605131; MGI: 1931237; HomoloGene: 56334; GeneCards: WWOX; OMA:WWOX - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q23.1-q23.2 Start 78,099,400 bp[1] End 79,212,667 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 115,166,395 bp[2] End 116,079,447 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland optic nerve glomerulus sural nerve metanephric glomerulus Epithelium of choroid plexus pars reticulata endothelial cell kidney tubule pars compacta Top expressed in interventricular septum neural layer of retina zygote amygdala visual cortex cerebellar cortex secondary oocyte primary visual cortex spermatocyte lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity protein dimerization activity protein binding enzyme binding oxidoreductase activity Cellular component cytoplasm cytosol Golgi apparatus plasma membrane microvillus RNA polymerase II transcription regulator complex mitochondrion nucleus Biological process cellular response to transforming growth factor beta stimulus steroid metabolic process extrinsic apoptotic signaling pathway negative regulation of Wnt signaling pathway skeletal system morphogenesis Wnt signaling pathway positive regulation of extrinsic apoptotic signaling pathway in absence of ligand osteoblast differentiation intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of extrinsic apoptotic signaling pathway positive regulation of transcription by RNA polymerase II apoptotic process negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51741 80707 Ensembl ENSG00000186153 ENSMUSG00000004637 UniProt Q9NZC7 Q91WL8 RefSeq (mRNA) NM_001291997 NM_016373 NM_018560 NM_130788 NM_130790 NM_130791 NM_130792 NM_130844 NM_019573 RefSeq (protein) NP_001278926 NP_057457 NP_570607 NP_062519 Location (UCSC) Chr 16: 78.1 – 79.21 Mb Chr 8: 115.17 – 116.08 Mb PubMed search [3] [4]
Wikidata
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Function

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.^[8]

WWOX is also known as human accelerated region 6. It may, therefore, have played a key role in differentiating humans from apes.^[9]

Interactions

WWOX has been shown to interact with P53 and ACK1.^[10][11]

Disorders

Defects in the WWOX gene are associated with a number of developmental disorders, including WOREE syndrome.^[12]