WNT1

WNT1 is a gene that encodes the WNT1 protein.^[5][6] It is a proto-oncogene involved in regulating embryonic development and is highly conserved among animals.^[7] WNT1 was previously known as INT1 in mammals and Wg (or "wingless") in Drosophila.^[8] In 1987, it was discovered that they were the same gene (i.e. they were homologous),^[9] and the gene was subsequently renamed WNT1, although it is sometimes still referred to by its previous names.

WNT1
Identifiers
Aliases	WNT1, BMND16, INT1, OI15, Wnt family member 1
External IDs	OMIM: 164820; MGI: 98953; HomoloGene: 3963; GeneCards: WNT1; OMA:WNT1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 48,978,322 bp[1] End 48,982,620 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F1|15 54.65 cM Start 98,687,738 bp[2] End 98,691,718 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte nucleus accumbens superior frontal gyrus right frontal lobe prefrontal cortex putamen blood caudate nucleus bone marrow Brodmann area 9 Top expressed in muscle layer of urethra pelvic part of vagina rhombic lip ejaculatory duct perineal part of vagina inner cell mass epithelium of seminiferous tubule of testis choroid plexus of fourth ventricle female urethra morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity protein domain specific binding frizzled binding morphogen activity signaling receptor binding receptor ligand activity Cellular component cytoplasm endocytic vesicle membrane endoplasmic reticulum lumen plasma membrane extracellular region cell surface Golgi lumen extracellular exosome extracellular space Biological process negative regulation of cell-substrate adhesion forebrain anterior/posterior pattern specification dopaminergic neuron differentiation neurogenesis cell fate commitment negative regulation of fat cell differentiation positive regulation of protein phosphorylation myotube differentiation metencephalon development midbrain-hindbrain boundary maturation during brain development T cell differentiation in thymus spinal cord association neuron differentiation negative regulation of cell-cell adhesion neuron fate determination signal transduction in response to DNA damage central nervous system morphogenesis positive regulation of fibroblast proliferation positive regulation of dermatome development cell-cell signaling negative regulation of cell differentiation hematopoietic stem cell proliferation cell proliferation in midbrain positive regulation of DNA-binding transcription factor activity embryonic axis specification hepatocyte differentiation negative regulation of transforming growth factor beta receptor signaling pathway cerebellum development ubiquitin-dependent SMAD protein catabolic process cerebellum formation negative regulation of BMP signaling pathway canonical Wnt signaling pathway involved in negative regulation of apoptotic process positive regulation of transcription, DNA-templated multicellular organism development diencephalon development branching involved in ureteric bud morphogenesis cellular response to peptide hormone stimulus midbrain-hindbrain boundary development embryonic brain development response to wounding positive regulation of insulin-like growth factor receptor signaling pathway inner ear morphogenesis animal organ regeneration positive regulation of cell population proliferation negative regulation of ubiquitin-dependent protein catabolic process neuron fate commitment myoblast fusion positive regulation of lamellipodium assembly bone development Spemann organizer formation midbrain development positive regulation of Notch signaling pathway positive regulation of transcription by RNA polymerase II Wnt signaling pathway astrocyte-dopaminergic neuron signaling positive regulation of canonical Wnt signaling pathway Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation midbrain dopaminergic neuron differentiation canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Wnt signaling pathway, planar cell polarity pathway beta-catenin destruction complex disassembly negative regulation of oxidative stress-induced neuron death regulation of signaling receptor activity canonical Wnt signaling pathway negative regulation of apoptotic process neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7471 22408 Ensembl ENSG00000125084 ENSMUSG00000022997 UniProt P04628 P04426 RefSeq (mRNA) NM_005430 NM_021279 RefSeq (protein) NP_005421 NP_067254 Location (UCSC) Chr 12: 48.98 – 48.98 Mb Chr 15: 98.69 – 98.69 Mb PubMed search [3] [4]
Wikidata
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The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.^[10]

See also

• Wnt signaling pathway