XAF1

XIAP-associated factor 1 is a protein that in humans is encoded by the XAF1 gene.^[5][6][7]

XAF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LXW
Identifiers
Aliases	XAF1, BIRC4BP, HSXIAPAF1, XIAPAF1, XIAP associated factor 1
External IDs	OMIM: 606717; MGI: 3772572; HomoloGene: 49488; GeneCards: XAF1; OMA:XAF1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 6,755,447 bp[1] End 6,775,647 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B4 Start 72,192,455 bp[2] End 72,204,559 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right ovary left ovary gallbladder right uterine tube monocyte right lobe of liver visceral pleura spleen endothelial cell Top expressed in decidua cervix right lung epithelium of small intestine right lung lobe subcutaneous adipose tissue carotid body gastrula sciatic nerve duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding zinc ion binding Cellular component cytosol cytoplasm nucleus mitochondrion Biological process apoptotic process type I interferon signaling pathway response to interferon-beta Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54739 327959 Ensembl ENSG00000132530 ENSMUSG00000040483 UniProt Q6GPH4 Q5NBU8 RefSeq (mRNA) NM_017523 NM_199139 NM_001353134 NM_001353135 NM_001353136 NM_001353137 NM_001353138 NM_001353139 NM_001353140 NM_001037713 NM_001291153 RefSeq (protein) NP_059993 NP_954590 NP_001340063 NP_001340064 NP_001340065 NP_001340066 NP_001340067 NP_001340068 NP_001340069 NP_001032802 NP_001278082 Location (UCSC) Chr 17: 6.76 – 6.78 Mb Chr 11: 72.19 – 72.2 Mb PubMed search [3] [4]
Wikidata
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Function

X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells (Liston et al., 2001).[supplied by OMIM]^[7]

Interactions

XAF1 has been shown to interact with XIAP.^[6]