XPNPEP2

Xaa-Pro aminopeptidase 2 is an enzyme that in humans is encoded by the XPNPEP2 gene.^[5][6][7]

XPNPEP2
Identifiers
Aliases	XPNPEP2, AEACEI, APP2, X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound, X-prolyl aminopeptidase 2
External IDs	OMIM: 300145; MGI: 2180001; HomoloGene: 37766; GeneCards: XPNPEP2; OMA:XPNPEP2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.1 Start 129,738,949 bp[1] End 129,769,536 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A4 Start 47,197,602 bp[2] End 47,225,858 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum jejunal mucosa kidney tubule glomerulus human kidney duodenum metanephric glomerulus gastric mucosa right coronary artery left coronary artery Top expressed in intestinal villus jejunum right kidney ileum proximal tubule embryo esophagus duodenum embryo gray matter layer of cerebellum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity aminopeptidase activity hydrolase activity metallopeptidase activity metal ion binding metalloaminopeptidase activity Cellular component anchored component of membrane extracellular exosome membrane extracellular region plasma membrane cytoplasm Biological process proteolysis C-terminal protein lipidation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7512 170745 Ensembl ENSG00000122121 ENSMUSG00000037005 UniProt O43895 B1AVD1 RefSeq (mRNA) NM_003399 NM_001289729 NM_133213 RefSeq (protein) NP_003390 NP_001276658 NP_573476 Location (UCSC) Chr X: 129.74 – 129.77 Mb Chr X: 47.2 – 47.23 Mb PubMed search [3] [4]
Wikidata
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Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes.^[7]