XPO6

Exportin-6 is a protein that in humans is encoded by the XPO6 gene.^[5][6]

XPO6
Identifiers
Aliases	XPO6, EXP6, RANBP20, exportin 6
External IDs	OMIM: 608411; MGI: 2429950; HomoloGene: 12544; GeneCards: XPO6; OMA:XPO6 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.1 Start 28,097,976 bp[1] End 28,211,965 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 125,700,887 bp[2] End 125,799,673 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood granulocyte left testis right testis spleen epithelium of colon C1 segment tibial nerve upper lobe of left lung right frontal lobe Top expressed in tail of embryo genital tubercle granulocyte spermatocyte dentate gyrus of hippocampal formation granule cell ventricular zone spermatid yolk sac epiblast seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nuclear export signal receptor activity Cellular component plasma membrane nucleolus nucleus cytoplasm cytosol protein-containing complex Biological process protein transport intracellular protein transport protein export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23214 74204 Ensembl ENSG00000169180 ENSMUSG00000000131 UniProt Q96QU8 Q924Z6 RefSeq (mRNA) NM_001270940 NM_015171 NM_028816 NM_001311143 RefSeq (protein) NP_001257869 NP_055986 NP_001298072 NP_083092 Location (UCSC) Chr 16: 28.1 – 28.21 Mb Chr 7: 125.7 – 125.8 Mb PubMed search [3] [4]
Wikidata
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Exportins, such as XPO6, recruit cargo in the nucleoplasm in the presence of Ran-GTP and form ternary export complexes. These complexes are transported through nuclear pore complexes to the cytoplasm, where GTP is hydrolyzed and the export complex is disassembled.^[6]