YAF2

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.^[5][6]

YAF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D9G
Identifiers
Aliases	YAF2, YY1 associated factor 2
External IDs	OMIM: 607534; MGI: 1914307; HomoloGene: 136401; GeneCards: YAF2; OMA:YAF2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q12 Start 42,157,104 bp[1] End 42,238,349 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E3 Start 93,182,159 bp[2] End 93,234,816 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right auricle of heart Achilles tendon gastrocnemius muscle epithelium of colon left ventricle muscle of thigh ventricular zone sural nerve ganglionic eminence gonad Top expressed in Region I of hippocampus proper barrel cortex epithelium of lens retinal pigment epithelium substantia nigra Epithelium of choroid plexus iris prefrontal cortex blood external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding transcription coactivator activity transcription corepressor activity Cellular component nucleus cytosol nucleoplasm Biological process positive regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of G0 to G1 transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10138 67057 Ensembl ENSG00000015153 ENSMUSG00000022634 UniProt Q8IY57 Q99LW6 RefSeq (mRNA) NM_001012424 NM_001190977 NM_001190979 NM_001190980 NM_005748 NM_001320080 NM_024189 RefSeq (protein) NP_001177906 NP_001177908 NP_001177909 NP_001307009 NP_005739 NP_077151 Location (UCSC) Chr 12: 42.16 – 42.24 Mb Chr 15: 93.18 – 93.23 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.^[6]