Tyrosine-protein kinase Yes

Tyrosine-protein kinase Yes is a non-receptor tyrosine kinase that in humans is encoded by the YES1 gene.^[5][6]

YES1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HDA
Identifiers
Aliases	YES1, HsT441, P61-YES, Yes, c-yes, YES proto-oncogene 1, Src family tyrosine kinase
External IDs	OMIM: 164880; MGI: 99147; HomoloGene: 55900; GeneCards: YES1; OMA:YES1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.32 Start 721,588 bp[1] End 812,546 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B1|5 17.33 cM Start 32,768,515 bp[2] End 32,844,401 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte jejunal mucosa parotid gland buccal mucosa cell visceral pleura gingival epithelium parietal pleura endothelial cell corpus epididymis lactiferous duct Top expressed in lumbar spinal ganglion cumulus cell left lung lobe tail of embryo migratory enteric neural crest cell seminal vesicula Rostral migratory stream genital tubercle Gonadal ridge zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity transmembrane transporter binding epidermal growth factor receptor binding non-membrane spanning protein tyrosine kinase activity kinase activity protein binding enzyme binding protein tyrosine kinase activity signaling receptor binding ATP binding phosphotyrosine residue binding Cellular component Golgi apparatus membrane focal adhesion extrinsic component of cytoplasmic side of plasma membrane plasma membrane microtubule organizing center actin filament extracellular exosome cytoskeleton cytoplasm cytosol glutamatergic synapse postsynaptic specialization, intracellular component Biological process cellular response to transforming growth factor beta stimulus cellular response to retinoic acid cell differentiation Fc-gamma receptor signaling pathway involved in phagocytosis phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway ephrin receptor signaling pathway T cell costimulation cellular response to platelet-derived growth factor stimulus protein phosphorylation regulation of vascular permeability regulation of cell population proliferation positive regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine autophosphorylation protein autophosphorylation leukocyte migration positive regulation of transcription by RNA polymerase II innate immune response cell migration regulation of glucose transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7525 22612 Ensembl ENSG00000176105 ENSMUSG00000014932 UniProt P07947 Q04736 RefSeq (mRNA) NM_005433 NM_001205132 NM_001205133 NM_009535 RefSeq (protein) NP_005424 NP_001192061 NP_001192062 NP_033561 Location (UCSC) Chr 18: 0.72 – 0.81 Mb Chr 5: 32.77 – 32.84 Mb PubMed search [3] [4]
Wikidata
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This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.^[6]

Interactions

YES1 has been shown to interact with Janus kinase 2,^[7] CTNND1,^[8] RPL10^[9] and Occludin.^[10]