YKT6

Synaptobrevin homolog YKT6 is a protein that in humans is encoded by the YKT6 gene.^[5][6][7]

YKT6
Identifiers
Aliases	YKT6, YKT6 v-SNARE homolog
External IDs	OMIM: 606209; MGI: 1927550; HomoloGene: 4778; GeneCards: YKT6; OMA:YKT6 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 44,200,959 bp[1] End 44,214,294 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 5,905,693 bp[2] End 5,917,780 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium islet of Langerhans body of pancreas mucosa of transverse colon C1 segment ganglionic eminence granulocyte body of stomach smooth muscle tissue right frontal lobe Top expressed in calvaria stroma of bone marrow molar body of femur pyloric antrum epithelium of stomach dermis transitional epithelium of urinary bladder skin of external ear lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-cysteine S-palmitoyltransferase activity transferase activity SNAP receptor activity SNARE binding cadherin binding protein binding Cellular component cytoplasm integral component of membrane endosome Golgi apparatus membrane Golgi membrane integral component of plasma membrane basal dendrite transport vesicle soma SNARE complex endoplasmic reticulum mitochondrion cytoplasmic vesicle membrane endoplasmic reticulum-Golgi intermediate compartment membrane cytoplasmic vesicle apical dendrite cytosol Biological process vesicle targeting vesicle docking involved in exocytosis endoplasmic reticulum to Golgi vesicle-mediated transport retrograde transport, endosome to Golgi protein transport vesicle fusion vesicle-mediated transport membrane fusion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10652 56418 Ensembl ENSG00000106636 ENSMUSG00000002741 UniProt O15498 Q9CQW1 RefSeq (mRNA) NM_006555 NM_001363678 NM_019661 RefSeq (protein) NP_006546 NP_001350607 NP_006546.1 NP_062635 Location (UCSC) Chr 7: 44.2 – 44.21 Mb Chr 11: 5.91 – 5.92 Mb PubMed search [3] [4]
Wikidata
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Function

This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway.^[7]

Interactions

YKT6 has been shown to interact with BET1L.^[8][9]