ZBTB7A

Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.^[5][6][7]

ZBTB7A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IF5, 2NN2
Identifiers
Aliases	ZBTB7A, FBI-1, FBI1, LRF, ZBTB7, ZNF857A, pokemon, TIP21, zinc finger and BTB domain containing 7A, MNDLFH
External IDs	OMIM: 605878; MGI: 1335091; HomoloGene: 7820; GeneCards: ZBTB7A; OMA:ZBTB7A - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 4,043,303 bp[1] End 4,066,899 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 80,971,054 bp[2] End 80,988,829 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple internal globus pallidus middle temporal gyrus pylorus cerebellar vermis Brodmann area 23 cardia vulva superior surface of tongue ventral tegmental area Top expressed in ascending aorta aortic valve inner renal medulla superior frontal gyrus glomerulus lip granulocyte right kidney esophagus cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding histone acetyltransferase binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription corepressor binding DNA-binding transcription factor activity transcription corepressor activity sequence-specific DNA binding SMAD binding androgen receptor binding Cellular component nucleus cytoplasm NuRD complex site of double-strand break DNA-dependent protein kinase complex Biological process multicellular organism development cell differentiation negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of alternative mRNA splicing, via spliceosome regulation of glycolytic process chromatin organization chromatin remodeling cellular response to DNA damage stimulus B cell differentiation negative regulation of transforming growth factor beta receptor signaling pathway protein localization to nucleus regulation of apoptotic process erythrocyte maturation fat cell differentiation negative regulation of Notch signaling pathway regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity negative regulation of androgen receptor signaling pathway double-strand break repair via classical nonhomologous end joining regulation of transcription regulatory region DNA binding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51341 16969 Ensembl ENSG00000178951 ENSMUSG00000035011 UniProt O95365 O88939 RefSeq (mRNA) NM_015898 NM_001317990 NM_020224 NM_010731 RefSeq (protein) NP_001304919 NP_056982 NP_034861 NP_001391790 NP_001391791 NP_001391792 NP_001391793 NP_001391794 NP_001391795 NP_001391796 Location (UCSC) Chr 19: 4.04 – 4.07 Mb Chr 10: 80.97 – 80.99 Mb PubMed search [3] [4]
Wikidata
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Interactions

ZBTB7A has been shown to interact with BCL6.^[8]

See also

• Zbtb7