ZBTB7B

Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene.^[5][6][7] ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes (e.g. COL1A1; MIM 120150) and has a role in development.[supplied by OMIM]^[7]

ZBTB7B
Identifiers
Aliases	ZBTB7B, THPOK, ZBTB15, ZFP-67, ZFP67, ZNF857B, c-KROX, hcKROX, CKROX, zinc finger and BTB domain containing 7B
External IDs	OMIM: 607646; MGI: 102755; HomoloGene: 7605; GeneCards: ZBTB7B; OMA:ZBTB7B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 155,002,630 bp[1] End 155,018,523 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.09 cM Start 89,284,951 bp[2] End 89,302,083 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte mucosa of transverse colon skin of abdomen skin of leg granulocyte nipple cardia body of stomach salivary gland mucosa of pharynx Top expressed in granulocyte pyloric antrum lip neural layer of retina tibiofemoral joint esophagus lens yolk sac muscle of thigh gastric mucosa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding metal ion binding nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding protein homodimerization activity histone deacetylase binding Cellular component nucleus nucleoplasm Biological process multicellular organism development ectoderm development cell differentiation regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated regulation of CD4-positive, alpha-beta T cell differentiation regulation of CD8-positive, alpha-beta T cell differentiation positive regulation of transcription by RNA polymerase II regulation of gene expression negative regulation of T-helper 17 cell differentiation lactation positive regulation of gene expression response to insulin positive regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of CD8-positive, alpha-beta T cell differentiation positive regulation of insulin receptor signaling pathway positive regulation of brown fat cell differentiation adaptive thermogenesis positive regulation of SREBP signaling pathway negative regulation of transcription by RNA polymerase II NK T cell differentiation negative regulation of gene expression positive regulation of histone deacetylation negative regulation of NK T cell proliferation positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51043 22724 Ensembl ENSG00000160685 ENSMUSG00000028042 UniProt O15156 Q64321 RefSeq (mRNA) NM_001252406 NM_001256455 NM_001377451 NM_001377452 NM_001377453 NM_001377454 NM_001377455 NM_009565 NM_001355206 NM_001355211 NM_001355212 RefSeq (protein) NP_001239335 NP_001243384 NP_001364380 NP_001364381 NP_001364382 NP_001364383 NP_001364384 NP_033591 NP_001342135 NP_001342140 NP_001342141 Location (UCSC) Chr 1: 155 – 155.02 Mb Chr 3: 89.28 – 89.3 Mb PubMed search [3] [4]
Wikidata
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See also

• Zbtb7