ZEB1

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.^[5][6][7]

ZEB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E19
Identifiers
Aliases	ZEB1, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
External IDs	OMIM: 189909; MGI: 1344313; HomoloGene: 31779; GeneCards: ZEB1; OMA:ZEB1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p11.22 Start 31,318,495 bp[1] End 31,529,814 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 4.42 cM|18 A1 Start 5,591,860 bp[2] End 5,775,467 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon epithelium of colon decidua optic nerve glutes endothelial cell Skeletal muscle tissue of rectus abdominis biceps brachii tendon of biceps brachii Skeletal muscle tissue of biceps brachii Top expressed in internal carotid artery substantia nigra motor neuron external carotid artery semi-lunar valve carotid body ascending aorta Rostral migratory stream suprachiasmatic nucleus Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription corepressor activity transcription coactivator activity zinc ion binding transcription factor binding chromatin binding metal ion binding protein binding nucleic acid binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity E-box binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleus nucleoplasm cytosol Biological process pattern specification process embryonic skeletal system morphogenesis regulation of smooth muscle cell differentiation animal organ development cell differentiation semicircular canal morphogenesis regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription, DNA-templated nervous system development regulation of transforming growth factor beta receptor signaling pathway regulation of T cell differentiation in thymus central nervous system development cartilage development regulation of mesenchymal cell proliferation embryonic camera-type eye morphogenesis cochlea morphogenesis immune response embryonic morphogenesis cellular response to amino acid stimulus cell population proliferation negative regulation of epithelial cell differentiation positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation negative regulation of transcription, DNA-templated positive regulation of neuron differentiation negative regulation of transcription by RNA polymerase II negative regulation of endothelial cell differentiation cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6935 21417 Ensembl ENSG00000148516 ENSMUSG00000024238 UniProt P37275 Q64318 RefSeq (mRNA) NM_001128128 NM_001174093 NM_001174094 NM_001174095 NM_001174096 NM_030751 NM_001323638 NM_001323641 NM_001323642 NM_001323643 NM_001323644 NM_001323645 NM_001323646 NM_001323647 NM_001323648 NM_001323649 NM_001323650 NM_001323651 NM_001323652 NM_001323653 NM_001323654 NM_001323655 NM_001323656 NM_001323657 NM_001323658 NM_001323659 NM_001323660 NM_001323661 NM_001323662 NM_001323663 NM_001323664 NM_001323665 NM_001323666 NM_001323671 NM_001323672 NM_001323673 NM_001323674 NM_001323675 NM_001323676 NM_001323677 NM_001323678 NM_011546 NM_001360981 NM_001360982 RefSeq (protein) NP_001121600 NP_001167564 NP_001167565 NP_001167566 NP_001167567 NP_001310567 NP_001310570 NP_001310571 NP_001310572 NP_001310573 NP_001310574 NP_001310575 NP_001310576 NP_001310577 NP_001310578 NP_001310579 NP_001310580 NP_001310581 NP_001310582 NP_001310583 NP_001310584 NP_001310585 NP_001310586 NP_001310587 NP_001310588 NP_001310589 NP_001310590 NP_001310591 NP_001310592 NP_001310593 NP_001310594 NP_001310595 NP_001310600 NP_001310601 NP_001310602 NP_001310603 NP_001310604 NP_001310605 NP_001310606 NP_001310607 NP_110378 NP_035676 NP_001347910 NP_001347911 Location (UCSC) Chr 10: 31.32 – 31.53 Mb Chr 18: 5.59 – 5.78 Mb PubMed search [3] [4]
Wikidata
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ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.^[7][6] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has seven zinc fingers and one homeodomain.^[8] The structure of the homeodomain is shown on the right.

Clinical significance

Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. ZEB1 downregulates E-cadherin and induces epithelial to mesenchymal transition in breast and other carcinomas^[9] A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.^[10] Overexpression of ZEB1 has been identified as a potential risk factor for recurrence and poor prognosis in several types of cancers.^[11]