ZFP36L1

Butyrate response factor 1 is a protein that in humans is encoded by the ZFP36L1 gene.^[5][6]

ZFP36L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W0V, 1W0W
Identifiers
Aliases	ZFP36L1, BRF1, Berg36, ERF-1, ERF1, RNF162B, TIS11B, cMG1, ZFP36 ring finger protein-like 1, ZFP36 ring finger protein like 1
External IDs	OMIM: 601064; MGI: 107946; HomoloGene: 31276; GeneCards: ZFP36L1; OMA:ZFP36L1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.1 Start 68,787,660 bp[1] End 68,796,253 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 80,154,528 bp[2] End 80,159,787 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of paranasal sinus canal of the cervix gastric mucosa right ovary ectocervix nipple left ovary urethra body of uterus right uterine tube Top expressed in corneal stroma genital tubercle ventricular zone lactiferous gland lip yolk sac esophagus cardiac muscle tissue of left ventricle superior surface of tongue atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity metal ion binding protein binding mRNA binding 14-3-3 protein binding RNA binding mRNA 3'-UTR AU-rich region binding DNA-binding transcription factor activity, RNA polymerase II-specific mRNA 3'-UTR binding Cellular component cytoplasm nucleus cytosol P-body ribonucleoprotein complex Biological process spongiotrophoblast layer development mRNA catabolic process multicellular organism growth embryonic organ development chorio-allantoic fusion vasculogenesis proepicardium development heart development nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay neural tube development cell population proliferation regulation of translation apoptotic process T cell differentiation in thymus regulation of gene expression negative regulation of erythrocyte differentiation cellular response to insulin stimulus cellular response to phorbol 13-acetate 12-myristate ERK1 and ERK2 cascade positive regulation of intracellular mRNA localization cellular response to glucocorticoid stimulus cellular response to transforming growth factor beta stimulus regulation of keratinocyte differentiation response to wounding positive regulation of monocyte differentiation regulation of transcription, DNA-templated cellular response to hypoxia regulation of keratinocyte apoptotic process regulation of keratinocyte proliferation phosphatidylinositol 3-kinase signaling cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus regulation of mRNA 3'-end processing MAPK cascade mRNA processing multicellular organism development nuclear-transcribed mRNA catabolic process, deadenylation-independent decay p38MAPK cascade regulation of mRNA stability protein kinase B signaling cellular response to fibroblast growth factor stimulus regulation of B cell differentiation positive regulation of fat cell differentiation regulation of myoblast differentiation mesendoderm development mRNA transport 3'-UTR-mediated mRNA destabilization cellular response to cAMP cellular response to peptide hormone stimulus cellular response to salt stress regulation of stem cell proliferation cellular response to raffinose positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of mitotic cell cycle phase transition transport regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 677 12192 Ensembl ENSG00000185650 ENSMUSG00000021127 UniProt Q07352 P23950 RefSeq (mRNA) NM_004926 NM_001244698 NM_001244701 NM_007564 RefSeq (protein) NP_001231627 NP_001231630 NP_004917 NP_031590 Location (UCSC) Chr 14: 68.79 – 68.8 Mb Chr 12: 80.15 – 80.16 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This RNA binding protein most likely functions in regulating the response to growth factors.^[6]

ZFP36L1 can degrade transcripts of numerous components of senescence-associated secretory phenotype (SASP) factors.^[7][8]

Interactions

ZFP36L1 has been shown to interact with MAPK14.^[9]