ZFX

This article is about the protein. For the flying effects company, see ZFX Inc.

Zinc finger X-chromosomal protein is a protein that in mammals is encoded by the ZFX gene of the X chromosome.^[5]

ZFX
Identifiers
Aliases	ZFX, ZNF926, zinc finger protein, X-linked, zinc finger protein X-linked
External IDs	OMIM: 314980; MGI: 99211; HomoloGene: 2561; GeneCards: ZFX; OMA:ZFX - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.11 Start 24,149,173 bp[1] End 24,216,255 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X C3|X 41.48 cM Start 93,118,237 bp[2] End 93,167,308 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve germinal epithelium epithelium of colon monocyte Skeletal muscle tissue of rectus abdominis testicle stromal cell of endometrium tibia Skeletal muscle tissue of biceps brachii Top expressed in medullary collecting duct renal corpuscle ciliary body vestibular sensory epithelium medial ganglionic eminence ureter Ileal epithelium iris primitive streak left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription coactivator activity metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm nucleolus Biological process multicellular organism development transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of nucleic acid-templated transcription ovarian follicle development germ cell development spermatogenesis fertilization post-embryonic development multicellular organism growth oocyte development homeostasis of number of cells parental behavior Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7543 22764 Ensembl ENSG00000005889 ENSMUSG00000079509 UniProt P17010 P17012 RefSeq (mRNA) NM_001178084 NM_001178085 NM_001178086 NM_001178095 NM_003410 NM_001330327 NM_001044386 NM_011768 NM_001358354 NM_001358355 NM_001358356 NM_001358357 RefSeq (protein) NP_001171555 NP_001171556 NP_001171557 NP_001171566 NP_001317256 NP_003401 NP_001037851 NP_035898 NP_001345283 NP_001345284 NP_001345285 NP_001345286 Location (UCSC) Chr X: 24.15 – 24.22 Mb Chr X: 93.12 – 93.17 Mb PubMed search [3] [4]
Wikidata
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Function

This gene on the X chromosome is structurally similar to a related gene on the Y chromosome (ZFY). It encodes a member of the krüppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]

Clinical significance

See also: X-linked intellectual disability

The gene is associated with X-linked neurodevelopmental disorder.^[6]

See also

• Kruppel-like factors