ZFYVE26

Zinc finger, FYVE domain containing 26 is a protein that in humans is encoded by the ZFYVE26 gene.^[5]

ZFYVE26
Identifiers
Aliases	ZFYVE26, FYVE-CENT, SPG15, zinc finger FYVE-type containing 26
External IDs	OMIM: 612012; MGI: 1924767; HomoloGene: 9102; GeneCards: ZFYVE26; OMA:ZFYVE26 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.1 Start 67,727,374 bp[1] End 67,816,590 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 79,279,120 bp[2] End 79,343,078 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve endothelial cell visceral pleura Skeletal muscle tissue of biceps brachii internal globus pallidus tendon of biceps brachii muscle of thigh epithelium of colon stromal cell of endometrium ventricular zone Top expressed in granulocyte zygote genital tubercle epithelium of small intestine neural layer of retina blastocyst left lobe of liver tail of embryo spermatocyte superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding lipid binding phosphatidylinositol-3-phosphate binding Cellular component cytoplasm lysosomal membrane centrosome cytoskeleton microtubule organizing center midbody Biological process cell division cell cycle cytokinesis double-strand break repair via homologous recombination DNA repair cellular response to DNA damage stimulus mitotic cytokinesis regulation of cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23503 211978 Ensembl ENSG00000072121 ENSMUSG00000066440 UniProt Q68DK2 Q5DU37 RefSeq (mRNA) NM_015346 NM_001008550 RefSeq (protein) NP_056161 NP_001008550 Location (UCSC) Chr 14: 67.73 – 67.82 Mb Chr 12: 79.28 – 79.34 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15.^[5]