ZHX1

Zinc fingers and homeoboxes protein 1 is a protein that in humans is encoded by the ZHX1 gene.^[5][6]

ZHX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ECB, 2GHF, 2LY9, 3NAR
Identifiers
Aliases	ZHX1, zinc fingers and homeoboxes 1
External IDs	OMIM: 604764; MGI: 109271; HomoloGene: 5225; GeneCards: ZHX1; OMA:ZHX1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.13 Start 123,248,451 bp[1] End 123,275,541 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D1 Start 57,910,399 bp[2] End 57,939,937 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm secondary oocyte Achilles tendon epithelium of lactiferous gland lactiferous duct pars reticulata cerebellar vermis internal globus pallidus medulla oblongata superior vestibular nucleus Top expressed in genital tubercle spermatocyte white adipose tissue uterus hippocampus proper dentate gyrus of hippocampal formation granule cell tail of embryo ovary quadriceps femoris muscle muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding transcription corepressor activity metal ion binding protein heterodimerization activity nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process cell differentiation negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11244 22770 Ensembl ENSG00000165156 ENSMUSG00000022361 UniProt Q9UKY1 P70121 RefSeq (mRNA) NM_001017926 NM_007222 NM_001042438 NM_009572 RefSeq (protein) NP_001017926 NP_009153 NP_001035903 NP_033598 Location (UCSC) Chr 8: 123.25 – 123.28 Mb Chr 15: 57.91 – 57.94 Mb PubMed search [3] [4]
Wikidata
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The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein.^[6]

Interactions

ZHX1 has been shown to interact with NFYA.^[5][7]