ZHX2

Zinc fingers and homeoboxes protein 2 is a protein that in humans is encoded by the ZHX2 gene.^[5][6][7]

ZHX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DMP, 3NAU
Identifiers
Aliases	ZHX2, AFR1, RAF, zinc fingers and homeoboxes 2
External IDs	OMIM: 609185; MGI: 2683087; HomoloGene: 8968; GeneCards: ZHX2; OMA:ZHX2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.13 Start 122,781,655 bp[1] End 122,974,510 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 D1|15 24.01 cM Start 57,558,061 bp[2] End 57,703,228 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superficial temporal artery dorsal motor nucleus of vagus nerve saphenous vein Skeletal muscle tissue of rectus abdominis inferior olivary nucleus internal globus pallidus Skeletal muscle tissue of biceps brachii right ventricle caput epididymis lactiferous duct Top expressed in knee joint triceps brachii muscle vastus lateralis muscle otolith organ temporal muscle utricle skeletal muscle tissue medial head of gastrocnemius muscle granulocyte sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding protein homodimerization activity transcription corepressor activity metal ion binding identical protein binding protein heterodimerization activity nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol plasma membrane Biological process regulation of transcription by RNA polymerase II negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II mRNA catabolic process negative regulation of neuron differentiation somatic stem cell population maintenance transcription, DNA-templated retinal bipolar neuron differentiation nervous system development cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22882 387609 Ensembl ENSG00000178764 ENSMUSG00000071757 UniProt Q9Y6X8 Q8C0C0 RefSeq (mRNA) NM_014943 NM_001362797 NM_199449 RefSeq (protein) NP_055758 NP_001349726 NP_955520 Location (UCSC) Chr 8: 122.78 – 122.97 Mb Chr 15: 57.56 – 57.7 Mb PubMed search [3] [4]
Wikidata
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The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.^[7]

See also

• Chromosome 8 (human)
• NFYA
• Protein dimer