ZNF300

Zinc finger protein 300 is a protein that in humans is encoded by the ZNF300 gene.^[3][4] The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and a likely transcription factor.

ZNF300
Identifiers
Aliases	ZNF300, zinc finger protein 300
External IDs	OMIM: 612429; HomoloGene: 56531; GeneCards: ZNF300; OMA:ZNF300 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.1 Start 150,894,392 bp[1] End 150,904,983 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone Achilles tendon gonad left ovary right ovary testicle metanephros left lobe of thyroid gland body of pancreas n/a More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus nucleolus Biological process regulation of transcription, DNA-templated transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91975 n/a Ensembl ENSG00000145908 n/a UniProt Q96RE9 n/a RefSeq (mRNA) NM_001172831 NM_001172832 NM_052860 n/a RefSeq (protein) NP_001166302 NP_001166303 NP_443092 n/a Location (UCSC) Chr 5: 150.89 – 150.9 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

It is antisense to the human gene, C16orf71, indicating possibility of regulated alternative expression.^[5]

Clinical relevance

It is associated with Crohn's disease.^[6]