ZNRD1

DNA-directed RNA polymerase I subunit RPA12 is an enzyme that in humans is encoded by the ZNRD1 gene.^[5][6][7]

POLR1H
Identifiers
Aliases	POLR1H, HTEX-6, Rpa12, TEX6, ZR14, hZR14, tctex-6, HTEX6, TCTEX6, zinc ribbon domain containing 1, RNA polymerase I subunit H, ZNRD1, A12.2
External IDs	OMIM: 607525; MGI: 1913386; HomoloGene: 40960; GeneCards: POLR1H; OMA:POLR1H - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 30,058,899 bp[1] End 30,064,909 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 37,265,248 bp[2] End 37,269,451 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte mucosa of transverse colon gonad lymph node blood appendix monocyte rectum spleen body of pancreas Top expressed in primitive streak maxillary prominence blastocyst mandibular prominence morula epiblast ventricular zone thymus otic placode endocardial cushion More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity zinc ion binding metal ion binding nucleic acid binding RNA polymerase I activity Cellular component nucleolus nucleus nucleoplasm RNA polymerase I complex Biological process transcription initiation from RNA polymerase I promoter epigenetic maintenance of chromatin in transcription-competent conformation nucleobase-containing compound metabolic process transcription, DNA-templated mRNA cleavage termination of RNA polymerase I transcription transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30834 66136 Ensembl ENSG00000206502 ENSG00000224859 ENSG00000235443 ENSG00000236949 ENSG00000235176 ENSG00000233795 ENSG00000236808 ENSG00000066379 ENSMUSG00000036315 UniProt Q9P1U0 Q2L6J2 Q791N7 RefSeq (mRNA) NM_001278785 NM_001278786 NM_014596 NM_170783 NM_023162 NM_001355422 RefSeq (protein) NP_001265714 NP_001265715 NP_055411 NP_740753 NP_001265714.1 NP_001265715.1 NP_055411.1 NP_740753.1 NP_075651 NP_001342351 Location (UCSC) Chr 6: 30.06 – 30.06 Mb Chr 17: 37.27 – 37.27 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein with similarity to the Saccharomyces cerevisiae Rpa12p subunit of RNA polymerase I. Alternate splicing of this gene results in two transcript variants encoding the same protein. Additional splice variants have been described, but their full-length sequences have not been determined.^[7]